Lamb, Claire J. C.; Nderitu, Bryan G.; McMurdo, Gemma; Tobin, John M.; Vilela, Filipe; Lee, Ai-Lan published the artcile< Auto-Tandem Catalysis: PdII-Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane-1,3-diones>, Category: pyridine-derivatives, the main research area is cyclopentanedione continuous flow preparation autocatalyzed dehydrogenation oxidative Heck coupling; aerobic oxidation; auto-tandem catalysis; one-pot synthesis; oxidative Heck; palladium.
A Pd(II) catalyst system has been used to successfully catalyze two mechanistically distinct reactions in a one-pot procedure: dehydrogenation of 2,2-disubstituted cyclopentane-1,3-diones and the subsequent oxidative Heck coupling. This auto-tandem catalytic reaction is applicable to both batch and continuous flow processes, with the latter being the first example of a tandem aerobic dehydrogenation/oxidative Heck in flow. In addition, a telescoped reaction involving enantioselective desymmetrization of the all-C quaternary center was successfully achieved.
Chemistry – A European Journal published new progress about Cyclopentanes Role: SPN (Synthetic Preparation), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Category: pyridine-derivatives.