Patel, Harshkumar H.; Prater, Matthew B.; Squire, Scott O.; Sigman, Matthew S. published the artcile< Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers>, Quality Control of 1416819-91-4, the main research area is chiral allylic aryl ether preparation palladium catalyzed alkenylation; enantioselective palladium catalyzed alkenylation acyclic enol ether.
This report details a palladium-catalyzed process to access highly functionalized, optically active allylic aryl ethers. A number of electron-deficient alkenyl triflates underwent enantioselective and site-selective coupling with acyclic aryl enol ethers in the presence of a chiral palladium catalyst. This transform provides chiral allylic ether products in high yields and excellent enantiomeric ratios, furnishing a unique disconnection to incorporate heteroatoms at a stereocenter. Finally, the applicability of the products to target synthesis was demonstrated through the formation of a chiral allylic alc. and the generation of a flavone-inspired product.
Journal of the American Chemical Society published new progress about Alkenylation. 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Quality Control of 1416819-91-4.