Yu, Hsien-Cheng; Islam, Shahidul M.; Mankad, Neal P. published the artcile< Cooperative Heterobimetallic Substrate Activation Enhances Catalytic Activity and Amplifies Regioselectivity in 1,4-Hydroboration of Pyridines>, Application of C6H4F3N, the main research area is cooperative catalyst NHC copper iron half sandwich regioselective borylation; pyridine regioselective borylation cooperative copper iron imidazolylidene catalyst; dihydropyridine boronate preparation regioselective hydroboration pyridine cooperative bimetallic catalyst.
Regioselective 1,4-hydroboration of pyridine derivatives and quinoline with pinacolborane is catalyzed efficiently by the heterobinuclear catalyst, (IPr)CuFeCp(CO)2, at only 2 mol % loading, providing access to valuable 1,4-dihydropyridine (1,4-DHP) products. A variety of reactive functional groups are tolerated in the pyridine 3-position, and sufficient catalytic activity was obtained for reduction of sterically hindered cases such as 3,5-disubstituted pyridines and even 4-substituted pyridines. Mechanistic experiments indicate that the superior catalytic activity and 1,4-regioselectivity of the Cu/Fe heterobinuclear catalyst, compared to the corresponding mononuclear Cu catalyst, is derived from biphilic cooperativity of two key catalytic intermediates: electrophilic CpFe(CO)2(Bpin) activates the pyridine substrates toward regioselective nucleophilic addition by (IPr)CuH.
ACS Catalysis published new progress about Boronic acids, esters Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.