Vydzhak, Roman N.; Panchishin, Svitlana Ya.; Kachaeva, Maryna V.; Pilyo, Stepan G.; Moskvina, Viktoriia S.; Shablykina, Olga V.; Kozytskiy, Andriy V.; Brovarets, Volodymyr S. published the artcile< Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones>, Application of C6H8N2, the main research area is dihydrochromenopyrrole dione preparation; hydroxyphenyl dihydropyrrolopyrazolone preparation; Chromeno[2,3-c]pyrroles; Combinatorial library; Dihydrochromeno[2,3-c]pyrrole-3,9-diones; Dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones; Multicomponent cyclization.
An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones I [R =H, 6,7-di-Me, 7-F, etc.; R1 = n-Pr, CH2CH2OH, 2-furylmethyl, etc.; Ar = Ph, 4-MeC6H4, 3,4,5-tri-MeOC6H2, etc.] using a multicomponent process was presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones II [R2 = H, 3,5-di-Me, 4-Me-5-Cl, etc.; R3 = 4-BrC6H4, 2-OHC6H4, 3-MeO-4-OHC6H3, etc.; R4 = n-Pr, CH2CH2OH, 2-ClC6H4CH2, etc.] via ring-opening strategy was developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products could be easily isolated by crystallization without the use of chromatog.
Molecular Diversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.