Cheung, Chi Wai; Shen, Ni; Wang, Shao-Peng; Ullah, Asim; Hu, Xile; Ma, Jun-An published the artcile< Manganese-mediated reductive amidation of esters with nitroarenes>, Electric Literature of 93-60-7, the main research area is aryl amide; ester nitroarene reductive amidation.
A convenient and efficient method to synthesize N-aryl amides RNHC(O)R1 (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, quinolin-6-yl, etc; R1 = n-C6H13, cyclohexyl, 4-chlorophenyl, pyridin-3-yl, etc.) via amidation of esters R1C(O)OR2 (R2 = Et, benzyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) with nitroarenes RNO2 was reported. In the presence of manganese metal, this amidation proceeded smoothly without the need for addnl. catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active mols. RNHC(O)R1 (R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = Ph; R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = benzyl) and intermediates I (X = H, Cl) to drug mols. e.g., II.
Organic Chemistry Frontiers published new progress about Amidation (reductive). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.