Pesti, Jaan A.; Huhn, George F.; Yin, Jianguo; Xing, Yide; Fortunak, Joseph M.; Earl, Richard A. published the artcile< Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent>, COA of Formula: C6H6FNO, the main research area is methylpyridine chlorination; pyridylmethyl methanesulfonate preparation alkylation reagent; fluoropyridinylmethylanthrone preparation; anthrone bisfluoropyridinylmethyl preparation.
2-Fluoro-4-methylpyridine is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 2-Fluoro-4-methanesulfonylmethylpyridine. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the title compound, a cognition enhancer drug candidate. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis. The chlorination of other methylpyridines was also investigated.
Journal of Organic Chemistry published new progress about Chlorination. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, COA of Formula: C6H6FNO.