Valipour, Mehdi; Chippindale, Ann M.; Kouzeli, Aynaz; Irannejad, Hamid published the artcile< A new and facile synthesis of N-benzyl-N'-acylureas via reaction of dibenzoylhydrazine carboxamide and benzylamines>, Application In Synthesis of 3731-53-1, the main research area is benzyl acylurea preparation; dibenzoylhydrazine carboxamide benzylamine amination.
Herein, a new method of synthesis of N-acylureas I (Ar = Ph, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, pyridin-3-yl, pyridin-4-yl) via reaction of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide and various benzylamines ArCH2NH2 was reported. Preparation of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide was performed by the treatment of 3-methylthio-5,6-bis(4-methoxyphenyl)-1,2,4-triazine with Oxone which leads to oxidation and triazine ring cleavage in high yield (82%). Five benzylamine derivatives I containing different electron donating and withdrawing substituents were used in this study. Yields for the conversion of dibenzoylhydrazine carboxamide to N-acylureas I were in the range of 40-55%.
Synthetic Communications published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.