Khlebnikov, Vladimir; Patel, Kalpesh; Zhou, Xiaojian; Reddy, M. Madhava; Su, Zhuoyi; Chiacchia, Fabrizio S.; Hansen, Henrik C. published the artcile< Synthesis of 2-aryl-4H-pyrano[2,3-b]pyridin-4-ones by a one-pot deprotection-cyclization reaction>, Category: pyridine-derivatives, the main research area is arylpyranopyridinone preparation deprotection cyclization.
Preparation of 2-aryl-4H-pyrano[2,3-b]pyridin-4-ones is reported. A one-pot, two-step process starting with substituted 2-alkoxynicotinates and acetophenones in the presence of pyridinium hydrochloride is used. The methodol. is compatible with a series of functional groups useful for the synthesis of second generation analogs, as part of our structure/activity relationship program. The method proved to be scalable (>100 g), allowing for efficient synthesis of material to support animal studies.
Tetrahedron published new progress about Flavonoids Role: SPN (Synthetic Preparation), PREP (Preparation). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.