Wang, Xia; Yang, Qiu-Xia; Long, Cheng-Yu; Tan, Yan; Qu, Yi-Xin; Su, Min-Hui; Huang, Si-Jie; Tan, Weihong; Wang, Xue-Qiang published the artcile< Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines>, Electric Literature of 22961-45-1, the main research area is heteroaryl alkyl ether amine nucleophilic amination; amine heteroaryl preparation anticancer activity green chem.
A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.
Organic Letters published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Electric Literature of 22961-45-1.