Ashimori, Atsuyuki; Ono, Taizo; Uchida, Takeshi; Ohtaki, Yutaka; Fukaya, Chikara; Watanabe, Masahiro; Yokoyama, Kazumasa published the artcile< Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives>, Application In Synthesis of 131747-55-2, the main research area is antihypertensive pyridyldihydropyridinedicarboxylate; pyridyldihydropyridine derivative hypotensive activity; calcium antagonist pyridyldihydropyridinedicarboxylate.
A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF3, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized.
Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Application In Synthesis of 131747-55-2.