Bhattacharyya, Manjit K.; Gogoi, Anshuman; Chetry, Sanjib; Dutta, Debajit; Verma, Akalesh K.; Sarma, Bipul; Franconetti, Antonio; Frontera, Antonio published the artcile< Antiproliferative evaluation and supramolecular association in Mn(II) and Zn(II) bipyridine complexes: Combined experimental and theoretical studies>, SDS of cas: 366-18-7, the main research area is manganese methylbenzoate bipyridine complex preparation crystal mol structure antiproliferative; zinc pyridinedicarboxylate bipyridine complex preparation crystal mol structure antiproliferative; Apoptosis; Cooperativity; Cytotoxicity; Docking; T-cell lymphoma; π–π stacking.
Two new coordination complexes viz. [Mn2(μ-O,O’-4-Mebz)2(bpy)2(μ2-H2O)(4-Mebz)2] (1) and [Zn(bpy)(pdc)(H2O)]·3.5H2O (2) (where bpy = 2,2′-bipyridine, 4-Mebz = 4-Me benzoate and pdc = 2,6-pyridine dicarboxylate) were synthesized and structurally characterized by single crystal x-ray diffraction, FT-IR, electronic spectroscopy, Thermogravimetric Anal. (TGA) and Powder x-ray diffraction (PXRD) techniques. Complex 1 consists of a dinuclear Mn(II) unit bridged by a solvent water mol. while 2 is a mononuclear complex. The supramol. assemblies found in the solid state of both complexes have been described. In 2, several π-stacking interactions modes have been further studied using D. Functional Theory (DFT) calculations Furthermore, the activity of the complexes against a few pathogenic bacteria has been studied and confirmed. Finally, the antiproliferative activities of both complexes have been studied in T-cell lymphoma cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, apoptosis assay and mol. docking simulation. Both the complexes exhibit gratifying cytotoxicity through apoptotic cell death with negligible cytotoxicity (∼5-10%) in normal cells. It is worth mentioning that Mn(II) and Zn(II) complexes exhibit interaction modes with highly expressed cancer target proteins under study with higher binding affinity and the results are comparable with reference inhibitors.
Journal of Inorganic Biochemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.