Domarco, Olaya; Kieler, Claudia; Pirker, Christine; Dinhof, Carina; Englinger, Bernhard; Reisecker, Johannes M.; Timelthaler, Gerald; Garcia, Marcos D.; Peinador, Carlos; Keppler, Bernhard K.; Berger, Walter; Terenzi, Alessio published the artcile< Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle>, HPLC of Formula: 3731-53-1, the main research area is platinum metallacycle duplex DNA quadruplex interaction; G-quadruplex; SCC; metallacycle; platinum; subcellular localization.
Metal-driven self-assembly afforded a multitude of fascinating supramol. coordination complexes (SCCs) with applications as catalysts, host-guest, and stimuli-responsive systems. However, the interest in the biol. applications of SCCs is only starting to emerge and thorough characterization of their behavior in biol. milieus is still lacking. Herein, we report on the synthesis and detailed in-cell tracking of a Pt2L2 metallacycle. We show that our hexagonal supramol. accumulates in cancer cell nuclei, exerting a distinctive blue fluorescence staining of chromatin resistant to UV photobleaching selectively in nucleolar G4-rich regions. SCC co-localizes with epitopes of the quadruplex-specific antibody BG4 and replaces other well-known G4 stabilizers. Moreover, the photophys. changes accompanying the metallacycle binding to G4s in solution (fluorescence quenching, absorption enhancement) also take place intracellularly, allowing its subcellular interaction tracking.
Angewandte Chemie, International Edition published new progress about Biocompatibility. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.