Application of 63071-13-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63071-13-6, name is 4-Chloropicolinaldehyde. A new synthetic method of this compound is introduced below.
Preparation of 4-chloro-2-(difluoromethyl)pyridine: To a solution of 4-chloropicolinaldehyde (1.0 grams, 7.06 mmol) in anhydrous CH2Cl2 (40 mL) cooled to -78 C was added Diethylaminosulfur trifluoride (3.7 mL, 28.2 mmol) over a 2 minute period. The solution was warmed to room temperature and stirred for 4 hours. The reaction mixture was cooled to 0 C, and was slowly quenched with the addition of a 1:1 mixutre of aquoues NaHCO3 (sat.) and 1M NaOH. The solution was extracted with CH2Cl2 (2x), and the organic layer was washed with water, brine, dried (Na2SO4) and concentrated to obtain a red brown oil (0.78 g, 68% yield). The product was used as is in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-13-6, its application will become more common.
Reference:
Patent; GlaxoSmithKline LLC; VU, Chi, B.; DISCH, Jeremy, S.; SPRINGER, Stephanie, K.; BLUM, Charles, A.; PERNI, Robert, B.; (212 pag.)EP2273992; (2016); B1;,
Pyridine – Wikipedia,
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