Wang, Chao; Rui, Xiyan; Si, Dongjuan; Dai, Rupeng; Zhu, Yueyue; Wen, Hongmei; Li, Wei; Liu, Jian published the artcile< Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines>, Quality Control of 3731-53-1, the main research area is aryl aldehyde aromatic amine copper catalyst tandem cyclization; biaryl oxadiazole preparation green chem; benzaldehyde benzylamine copper catalyst tandem cyclization green chem; diphenyl quinazoline preparation.
The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazoles and quinazolines derivatives from readily available benzaldehydes, benzylamines and hydroxylamine or anilines was developed. Both the cascade reaction sequences involved nucleophilic addition of C-N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation This synthesis methodol. demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provided strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials.
Advanced Synthesis & Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.