Analyzing the synthesis route of 5-Bromo-4-methoxypyridin-2-amine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1232431-11-6, 5-Bromo-4-methoxypyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference of 1232431-11-6 ,Some common heterocyclic compound, 1232431-11-6, molecular formula is C6H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-4-methoxy-pyridin-2-ylamine (9.50 g, 46.79 mmol), hexane-2, 5-dione (7.08 mL, 60.83 mmol) and p-toluenesulfonic acid (0.81 g, 4.68 mmol) in toluene (80 mL) are stirred over night at l20C using a Dean-Stark-apparatus. The reaction mixture is concentrated under reduced pressure, taken up in DCM and purified by silica gel chromatography (DCM). Yield: 7.60 g (58%) ESI-MS: m/z = 281 and 283 [M+H]+ (Br-isotopic pattern) Rt(HPLC): 1.13 min (method 1)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1232431-11-6, 5-Bromo-4-methoxypyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BERRY, Angela Kay; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; NETHERTON, Matthew Russell; (119 pag.)WO2019/161010; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem