Reference of 7379-35-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7379-35-3, name is 4-Chloropyridine hydrochloride, molecular formula is C5H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a suspension of sodium 2-methylpropan-2-oiate (23 g, 2,478 mmoi) in DM50(700 mL), a solution of i,4-dioxaspiro[4.Sjdecan-8-ol (196 g, 1,239 mmol) in DM50 (300 mL) was added followed by 4-chioropyridinc hydrochloride (186 g. 1,239 mmoi) portion-wise while maintaining the temperature below 40 ¡ãC with a water bath, The rnizture was then heated at 0 ?C for 4 h until the complete disappearance of the starting material. The mixtnre was then quenched with 100 mL of water and partially concentrated to remove most of the DM50 (waterbath at 0 ?C). The resulting viscous material was then diluted with water and extracted with EtOAc three times. The organic layers were combined and dried over MgSO4 and concentrated to afford 4-(1,4-dioxaspiro[4.5]decan–yloxy)pyridine as beige sohd, The solid was transferred to a vacuum filter cup, washed with a minimum amount of MTBE twice at room temperature, and dried under reduced pressure to give the title compound as a light-brown solid (254.5 g,87percent). The mother liquor was concentrated to give a wet solid which was triturated with MTBE. The resulting solid was removed by filtration and washed with a minimum amount of MTBE to give a second crop of the title compound as a light-brown solid (14 g, 4.8percent). Exact mass caicniatcd for Cj3F117N03: 23.5.3.) found LCMS rn/a =236.0 [M+i-1]t.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7379-35-3, 4-Chloropyridine hydrochloride.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; THE UNIVERSITY OF COPENHAGEN; JONES, Robert M.; SCHWARTZ, Thue Walter; KRISTENSEN, Line Vildbrad; MADSEN, Torben Andreas Nygaard; WO2014/74700; (2014); A1;,
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