Adding a certain compound to certain chemical reactions, such as: 800401-68-7, 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. Recommanded Product: 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
To a solution OF 5-CHLORO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid (Preparation 18,223mg, 1.13mmol) and commercially available (lS, 2S)- (+)-2- AMINO-3-METHOXY-1-PHENYL-1-PROPANOL (200mg, L. 10MMOL) in DMF (5mL) was added HOBt (173mg, 1. 13MMOL), DIPEA (0.42mL, 2. 41mmol) and EDCI (260mg, 1. 36mmol). After stirring at rt for 12h the mixture was added to diluted brine (100mL, water/brine: 1/1). Extraction with ethyl acetate (4 x 25mL), washing of the combined extracts with diluted hydrochloric acid (1M, 30ML), diluted aqueous sodium hydroxide solution (1M, 30ML) and brine (30mL) followed by drying over magnesium sulphate gave after concentration a residue which was purified by flash chromatography on silica gel (eluent: ethyl acetate). The title compound was obtained as colourless solid. 8H (CD30D): 3.37 (3H, s), 3.34 (1H, dd), 3.66 (1H, dd), 4.53 (1H, ddd), 5.03 (1H, d), 7.15 (1H, s), 7.25-7. 45 (5H, 3m), 7.68 (1H, s), 8.58 (1H, s); m/z (ES+) = 360.22 [M+ H] + ; RT = 3. 12MIN.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,800401-68-7, 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem