In 2022,Ryan, Christopher A.; Baskevics, Vladislavs; Katkevics, Martins; Rozners, Eriks published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA》.Related Products of 141-86-6 The author mentioned the following in the article:
In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Ab initio and mol. dynamics simulations provided insights into H-bonding interactions that stabilized V·C-G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)
2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6