Adak, Laksmikanta; Jin, Masayoshi; Saito, Shota; Kawabata, Tatsuya; Itoh, Takuma; Ito, Shingo; Sharma, Akhilesh K.; Gower, Nicholas J.; Cogswell, Paul; Geldsetzer, Jan; Takaya, Hikaru; Isozaki, Katsuhiro; Nakamura, Masaharu published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iron-catalyzed enantioselective carbometalation of azabicycloalkenes》.Application In Synthesis of 5-Bromo-2-chloropyridine The article contains the following contents:
The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to in situ form optically active organozinc intermediates, which are amenable to further synthetic elaborations. The observed chiral induction, along with the DFT and XAS analyses, reveals the direct coordination of the chiral phosphine ligand to the iron center during the carbon-carbon and carbon-metal bond forming step. This new class of iron-catalyzed asym. reaction will contribute to the synthesis and production of bioactive mols. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 5-Bromo-2-chloropyridine