Name: 2-(2-Hydroxyethyl)pyridineIn 2020 ,《Synthesis and antimicrobial activities of Schiff base from nitrogen containing heterocycles》 was published in Journal of Applicable Chemistry (Lumami, India). The article was written by Maisuriya, Pratik K.; Soni, Hetal I.; Patel, Jaydeep A.; Patel, Navin B.. The article contains the following contents:
This article dealt with microwave assisted synthesis of Schiff bases N-(aryl)(((pyridinyl)ethoxy)phenyl)methanimines I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] from (2-(pyridinyl)ethoxy)benzaldehyde using catalytically amount of concentrateH2SO4 at room temperature MW stimulated synthetic route provided diverse advantages such as reaction rate acceleration, less byproduct, higher yield and reproducibility of final product. The structure of final compounds was established by elemental anal. such as IR, 1H NMR, 13C NMR, mass spectroscopy and also evaluated for their antibacterial, antifungal potency. The biol. potent Schiff base I [R = benzothiazol-2-yl] was found most active against S. aureus (MIC=25μg mL-1) with subjected to reference drug chloramphenicol and ciprofloxacin. The final compounds I [R = 3-ClC6H4, 4-ClC6H4, benzothiazol-2-yl] displayed good antibacterial activity (MIC=50μg mL-1) with reference drug. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-(2-Hydroxyethyl)pyridine