As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 588729-99-1, name is 3-Amino-5-bromo-2-chloropyridine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H4BrClN2
General procedure: To a solution of 1 (2.57mmol) in 8mL pyridine at 0C was added the pyridine solution of 4- fluoro sulfonyl chloride (4g, 19.4mmol) in drops and DMAP (20mg) to start the reaction. The mixture was warmed slowly to room temperature and stirred overnight. After the completion of the reaction (monitored by TLC), the reaction was quenched with water (30mL) and filtered. The filter cake was washed with water and EtOH to obtain white solid which was dissolved in MeOH (10mL) and added with 3mL saturated potassium carbonate solution. The mixture was stirred at room temperature for 6h and monitored by TLC. The reaction was quenched with water and extracted with EtOAc. The organic layer was collected and washed with water for three times, dried over anhydrous Na2SO4 and concentrated in vacuo. The crude material was purified by column chromatography to afford white solid.
With the rapid development of chemical substances, we look forward to future research findings about 588729-99-1.
Reference:
Article; Yan, Guoyi; Pu, Chunlan; Lan, Suke; Zhong, Xinxin; Zhou, Meng; Hou, Xueyan; Yang, Jie; Shan, Huifang; Zhao, Lifeng; Li, Rui; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 667 – 686;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem