In 2022,Li, Heng-Hui; Li, Shaoyu; Cheng, Jun Kee; Xiang, Shao-Hua; Tan, Bin published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Direct arylation of N-heterocycles enabled by photoredox catalysis》.Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:
N-Heterobiaryls are common skeletons found in biol. mols., pharmaceuticals and ligands. Herein, authors document an efficient and redox-neutral photocatalytic system to obtain functionalized N-heterobiaryls under mild conditions. Substrates bearing variegated functional groups are compatible with the developed photocatalytic conditions. This method is translatable to gram-scale synthesis, with a photocatalyst loading as low as 0.1 mol% and minimal variation of the yield. The starting materials are com. available, demonstrating the practicality and accessibility of this methodol. Interestingly, phenols can serve both as coupling partners and proton donors. Arenes without a phenolic hydroxyl group also underwent efficient coupling with HFIP as a solvent. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-Bromo-5-methylpyridine