Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 76469-41-5, name is 2,3,5-Trifluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
Step 1 (0493) To a solution of A16 (50 mg, 0.11 mmol) and 2,3,5-trifluoropyridine (30.0 mg, 0.23 mmol) in DMSO (2 mL) was added Cs2C03 (74 mg, 0.225 mmol) and the mixture was stirred at 60C for 1 h. The reaction mixture was quenched with water (15 mL) and extracted with EtOAc (4 x 25 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2S04, filtered and concentrated to give a mixture of D1/D2 as brown oil which was used in the next step without further purification Step 2 TFA (0.5 mL, 6.5 mmol) was added to a solution of a mixture of D1 D2 (60 mg, 0.11 mmol) in DCM (2.5 mL). The mixture was stirred at 15 C for 2 h, then concentrated and purified by p- HPLC (TFA) to afford a mixture of D3 D4 The mixture of D3 D4 (30 mg, 0.066 mmol) was separated by SFC (Column AD, 250 mm x 30 mm, 5um) to give Example 5 (tR = 2.564 min) and Example 6 (tR = 2.779 min). Step 3 The mixture of D3 D4 (30 mg, 0.066 mmol) was separated by SFC (Column AD, 250 mm x 30 mm, 5um) to give Example 5 (tR = 2.564 min) and Example 6 (tR = 2.779 min).
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Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CUMMING, Jared, N.; DAI, Xing; (84 pag.)WO2017/139210; (2017); A1;,
Pyridine – Wikipedia,
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