In 2019,Applied Organometallic Chemistry included an article by Thimma Sambamoorthy, Manikandan; Rengan, Ramesh; Jan Grzegorz, Malecki. Product Details of 3510-66-5. The article was titled 《Efficient construction of C-C bonds from aryl halides/aryl esters with arylboronic acids catalyzed by palladium(II) thiourea complexes》. The information in the text is summarized as follows:
A new set of palladium(II) complexes comprising phenyl(thiazolyl)thiourea ligands I (R = H, Me, NO2) have been successfully synthesized and characterized with the aid of anal. as well as spectral (IR, UV-visible and NMR) methods. A distorted square-planar geometry with N^S coordination mode of thiourea ligands in the new palladium complexes I (R = H, Me) was corroborated by single-crystal X-ray diffraction methods. Interestingly, the palladium(II) thiourea complexes I showed the highest catalytic activity with 0.1 mol% catalyst loading in Suzuki-Miyaura cross-coupling reactions utilizing a range of aryl halides RX (R = 4-acetylphenyl, 5-methylpyridin-2-yl, pyridin-2-yl, etc.; X = Br, Cl) with arylboronic acids R1B(OH)2 (R1 = Ph, 4-chlorophenyl, 6-bromopyridin-3-yl, etc.) as coupling partners in aqueous-organic media. Syntheses of diaryl ketones PhCOR1 using Ph benzoate and arylboronic acids as coupling partners were also achieved with low catalyst loading within 20 h. The potential of prepared catalyst was demonstrated by its wide substrate scope, low catalyst loadings and high isolated yield. Moreover, the influences of key parameters like solvent, base, temperature and catalyst loading were also investigated. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 3510-66-5