In 2018,Sattigeri, Jitendra A.; Garg, Malvika; Bhateja, Pragya; Soni, Ajay; Rauf, Abdul Rehman Abdul; Gupta, Mahendrakumar; Deshmukh, Mahesh S.; Jain, Tarun; Alekar, Nidhi; Barman, Tarani Kanta; Jha, Paras; Chaira, Tridib; Bambal, Ramesh B.; Upadhyay, Dilip J.; Nishi, Takahide published 《Synthesis and evaluation of thiomannosides, potent and orally active FimH inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Application In Synthesis of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:
FimH is a type I fimbrial lectin located at the tip of type-1 pili of Gram-neg. uropathogenic Escherichia coli (UPEC) guiding its ability to adhere and infect urothelial cells. Accordingly, blocking FimH with small mol. inhibitor is considered as a promising new therapeutic alternative to treat urinary tract infections caused by UPEC. Herein, we report that compounds having the S-glycosidic bond (thiomannosides) had improved metabolic stability and plasma exposures when dosed orally. Especially compound 5h showed the potential to inhibit biofilm formation and also to disrupt the preformed biofilm. And compound 5h showed prophylactic effect in UTI model in mice. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application In Synthesis of 5-Bromo-2-chloropyridine