Stevenson, Bernard G.; Spielvogel, Ethan H.; Loiaconi, Emily A.; Wambua, Victor Mulwa; Nakhamiyayev, Roman V.; Swierk, John R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Mechanistic Investigations of an α-Aminoarylation Photoredox Reaction》.Electric Literature of C33H24IrN3 The article contains the following contents:
While photoredox catalysis continues to transform modern synthetic chem., detailed mechanistic studies involving direct observation of reaction intermediates and rate constants are rare. By use of a combination of steady state photochem. measurements, transient laser spectroscopy, and electrochem. methods, an α-aminoarylation mechanism that is the inspiration for a large number of photoredox reactions was rigorously characterized. Despite high product yields, the external quantum yield (QY) of the reaction remained low (15-30%). By use of transient absorption spectroscopy, productive and unproductive reaction pathways were identified and rate constants assigned to develop a comprehensive mechanistic picture of the reaction. The role of the cyanoarene, 1,4-dicyanobenzne, was found to be unexpectedly complex, functioning both as initial proton acceptor in the reaction and as a neutral stabilizer for the 1,4-dicyanobenzene radical anion. Finally, kinetic modeling was utilized to analyze the reaction at an unprecedented level of understanding. This modeling demonstrated that the reaction is limited not by the kinetics of the individual steps but instead by scattering losses and parasitic absorption by a photochem. inactive donor-acceptor complex. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)
fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C33H24IrN3