Application of 82205-58-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine, molecular formula is C9H12N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(General acetylation/sulphonylation procedure). Compound 3b (208 mg, 1 mmol), acetyl chloride (79 mul, 1.1 mmol) and PS-NMM (100 mg) in CH2Cl2 (5 mL) were stirred for 16 h. After adding PS-Trisamine (150 mg) to the reaction mixture was left to stir for a further 2 h, filtered and concentrated in vacuum to afford a yellow solid: 250 mg (90%) yield. 1H NMR CDCl3 delta = 9.03 (1H, d, J = 2.5 Hz), 8.23 (1H, dd, J1, J2 = 2.9 Hz), 6.59 (1H, d, J = 9.5 Hz), 3.89-3.58 (8H, m), 2.13 (3H, s). 13C NMR CDCl3 delta = 169.4, 160.2, 146.2, 135.5, 133.2, 104.7, 44.7 (2C), 44.3 (2C), 21.4. IR (neat, cm-1): 1643, 1596, 1512, 1424, 1340, 1299, 929. HRMS m/z calculated for C11H15N4O3 (MH+): 251.1139, Found: 251.1140.
According to the analysis of related databases, 82205-58-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Tetrahedron Letters; vol. 52; 45; (2011); p. 5905 – 5909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem