Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2017 ,《(Aminomethylene)phosphonate Analogues as ZnII Chelators: Synthesis and Characterization》 appeared in European Journal of Inorganic Chemistry. The author of the article were Hevroni, Bosmat Levi; Jantz, Thomas; Gottlieb, Hugo E.; Fischer, Bilha. The article conveys some information:
A series of (aminomethylene)phosphonate (AMP) analogs, 8-14, bearing one or two heterocyclic moieties (imidazolyl, pyridyl, and thiazolyl) on the aminomethylene group, were synthesized as potential ZnII chelators. The complexes of analogs 8-14 with ZnII ions were characterized by their stoichiometry, geometry, coordination sites, acid/base equilibrium, and stability constants Analogs 8-14 form stable water-soluble 2:1 L/ZnII complexes, as established by ZnII titration, monitored by UV/visible spectrophotometry and by 1H and 31P NMR spectroscopy. Acidity and stability constants were established for each derivative by potentiometric pH titrations ML2 type ZnII complexes of AMP, bearing either an imidazolyl or pyridyl moiety, 8, 10, and 12, exhibit high log β values (17.68, 16.92, and 16.65, resp.), while for the AMP-thiazolyl (14) complex with ZnII, log β is 12.53. Generally, ligands 9, 11, and 13, bearing two heterocyclic moieties, present higher log β values (22.25, 21.00, and 18.28, resp.) vs. analogs bearing one heterocyclic moiety. Addnl., based on 1H, 13C, and 31P NMR spectroscopic data, the authors propose a structure of the AMP-(Im)2-ZnII complex in solution, where the ZnII coordination sites involve the phosphonate moiety and both imidazolyl rings of the two binding mols., forming an octahedral geometry around the ZnII ion. In summary, the authors propose a new family of water-soluble high-affinity ZnII chelators, in particular AMP-(Im)2, which forms the most stable complex (log β 22).2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide