The author of 《Electrochemical Reduction of the Carbonyl Functional Group: The Importance of Adsorption Geometry, Molecular Structure, and Electrode Surface Structure》 were Bondue, Christoph J.; Koper, Marc T. M.. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:
This paper studies the electrochem. hydrogenation of the carbonyl functional group of acetophenone and 4-acetylpyridine at platinum single-crystal electrodes. Comparison with results obtained for the hydrogenation of acetone featuring an isolated carbonyl functional group reveals the influence of the Ph ring and the pyridine ring, resp. Lack of acetone adsorption at Pt(111) and Pt(100) due to a weak interaction between surface and carbonyl functional group renders these surfaces inactive for the hydrogenation of acetone. Adsorption through a strong interaction with the Ph ring of acetophenone activates the Pt(111) and Pt(100) surfaces for hydrogenation of the acetyl substituent. In agreement with previous results for acetone reduction, the Pt(100) surface is specifically active for the hydrogenolysis reaction, breaking the C-O bond, whereas the other surfaces only hydrogenate the carbonyl functionality. In contrast to the Ph ring, the pyridine ring has a very different effect: due to the dominant interaction of the N atom of the pyridine ring with the platinum electrode, a vertical adsorption mode is realized. The resulting large phys. distance between the carbonyl functional group and the electrode surface inhibits the hydrogenation at all platinum surfaces. This also holds for the Pt(110) electrode, which is otherwise active for the electrochem. hydrogenation of the isolated carbonyl functional group of aliphatic ketones. Our results show how the combination of mol. structure of the reactant and surface structure of the catalyst determine the selective electroreduction of functionalized ketones.4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1122-54-9