In 2017,Keylor, Mitchell H.; Niemeyer, Zachary L.; Sigman, Matthew S.; Tan, Kian L. published 《Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines》.Journal of the American Chemical Society published the findings.Formula: C5H3BrClN The information in the text is summarized as follows:
A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bis[bis(dimethylamino)phosphino]ferrocene “”DMAPF””, a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Formula: C5H3BrClN)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Formula: C5H3BrClN