《Tricyclic imidazole antagonists of the Neuropeptide S Receptor》 was written by Trotter, B. Wesley; Nanda, Kausik K.; Manley, Peter J.; Uebele, Victor N.; Condra, Cindra L.; Gotter, Anthony L.; Menzel, Karsten; Henault, Martin; Stocco, Rino; Renger, John J.; Hartman, George D.; Bilodeau, Mark T.. Quality Control of Methyl 5-bromopicolinateThis research focused ontricyclic imidazole antagonist Neuropeptide S Receptor preparation. The article conveys some information:
A new structural class of potent antagonists of the Neuropeptide S Receptor (NPSR) is reported. High-throughput screening identified a tricyclic imidazole antagonist of NPSR, and medicinal chem. optimization of this structure was undertaken to improve potency against the receptor as well as CNS penetration. Detailed herein are synthetic and medicinal chem. studies that led to the identification of antagonists I and II which demonstrate potent in vitro NPSR antagonism and central exposure in vivo. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of Methyl 5-bromopicolinate