《Ruthenium-Catalyzed C-H Bond Heteroarylation of Triazoles Enabled by a Deconvolution Strategy》 was written by Gramage-Doria, Rafael; Roisnel, Thierry. Related Products of 53939-30-3This research focused ontriazolyl biaryl teraryl chemoselective regioselective preparation; optimization catalyst base solvent directed arylation phenyltriazole bromoarene; ruthenium catalyst regioselective monoarylation diarylation phenyltriazole bromoarene. The article conveys some information:
The ruthenium-catalyzed regioselective arylation of phenyltriazole I with aryl and heteroaryl bromides was optimized using a convolution strategy in which mixtures of carboxylate salts and bases were used instead of single reagents to minimize the number of experiments required to find optimal conditions. In the presence of [RuCl2(p-cymene)]2 and using potassium acetate and potassium carbonate as reagents in N-methyl-2-pyrrolidinone, I underwent regioselective directed mono- and diarylation reactions with aryl and heteroaryl bromides (depending on stoichiometry) such as 4-bromopyridine to yield triazolyl biaryls and teraryls such as II (R = H, 4-pyridinyl); 3-bromobenzonitrile and 2-bromotoluene (bearing meta and ortho substituents) were effective aryl bromides in the arylation.5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Related Products of 53939-30-3