In 2022,McFadden, Timothy Patrick; Nwachukwu, Chideraa Iheanyi; Roberts, Andrew George published an article in Organic & Biomolecular Chemistry. The title of the article was 《An amine template strategy to construct successive C-C bonds: synthesis of benzo[h]quinolines by a deaminative ring contraction cascade》.Reference of 2-Bromonicotinaldehyde The author mentioned the following in the article:
A convergent strategy to build, cyclize and excise nitrogen from tertiary amines for the synthesis of polyheterocyclic aromatics was developed. Biaryl-linked azepine intermediates underwent a deaminative ring contraction cascade reaction, excising nitrogen with the formation of an aromatic core. This strategy and deaminative ring contraction reaction was useful for the synthesis of benzo[h]quinolines. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Bromonicotinaldehyde