In 2019,International Journal of Molecular Sciences included an article by Marx, Sebastien; Bodart, Laurie; Tumanov, Nikolay; Wouters, Johan. Electric Literature of C6H7Br2N. The article was titled 《Design and synthesis of a new soluble natural β-carboline derivative for preclinical study by intravenous injection》. The information in the text is summarized as follows:
Harmine is a natural β-carboline compound showing several biol. activities, including antiproliferative properties, but this soluble natural mol. lacks selectivity. Harmine derivatives were reported to overcome this problem, but they are usually poorly soluble Here, we designed and synthesized a new 2, 7, 9-trisubstituted mol. (1-methyl-7-(3-methylbutoxy)-9- propyl-2-[(pyridin-2-yl)methyl]-9H-pyrido[3,4-b]indol-2-ium bromide) with a solubility of 1.87 ± 0.07 mg/mL in a simulated injection vehicle. This compound is stable for at least 72 h in acidic and physiol. conditions (pH 1.1 and 7.4) as well as in a simulated injection vehicle (physiol. liquid + 0.1% Tween 80). Solubility in those media is 1.06 ± 0.08 mg/mL and 1.62 ± 0.13 mg/mL at pH 7.4 and 1. The synthesized mol. displays a significant activity on five different cancer cell lines (IC50 range from 0.2 to 2 μM on A549, MDA-MB-231, PANC-1, T98G and Hs683 cell lines). This compound is also more active on cancer cells (MDA-MB-231) than on normal cells (MCF-10a) at IC50 concentrations Due to its high activity at low concentration, such solubility values should be sufficient for further in vivo antitumoral activity evaluation via i.v. injection. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H7Br2N