Reference of 2-Bromo-5-methylpyridineIn 2022 ,《Potassium tert-butoxide promoted regioselective deuteration of pyridines》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Li, Yan; Zheng, Chenxu; Jiang, Zhi-Jiang; Tang, Jianbo; Tang, Bencan; Gao, Zhanghua. The article conveys some information:
A regioselective deuteration at the β- and γ-position of pyridines was reported. Efficient deuteration occurred with a combination of KOtBu and DMSO-d6, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-Bromo-5-methylpyridine