Bazin, Marc-Antoine; Cojean, Sandrine; Pagniez, Fabrice; Bernadat, Guillaume; Cave, Christian; Ourliac-Garnier, Isabelle; Nourrisson, Marie-Renee; Morgado, Cathy; Picot, Carine; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Spath, Gerald F.; Rachidi, Najma; Bach, Stephane; Loiseau, Philippe M.; Le Pape, Patrice; Marchand, Pascal published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition》.Application of 1692-25-7 The article contains the following contents:
Leishmaniasis constitutes a severe public health problem, with an estimated prevalence of 12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the fatal Visceral Leishmaniasis (VL) was declared as new emerging disease in Europe, mainly due to global warming, with expected important public health impact. The available treatments are toxic, costly or lead to parasite resistance, thus there is an urgent need for new drugs with new mechanism of action. Previously, we reported the discovery of CTN1122, a potent imidazo[1,2-a]pyrazine-based antileishmanial hit compound targeting L-CK1.2 at low micromolar ranges. Here, we described structurally related, safe and selective compounds endowed with antiparasitic properties, better than miltefosine, the reference therapy by oral route. L-CK1.2 homol. model gave the first structural explanations of the role of 4-pyridyl (CTN1122) and 2-aminopyrimidin-4-yl (compound 21) moieties, at the position 3 of the central core, in the low micromolar to nanomolar L-CK1.2 inhibition, whereas N-methylpyrazole derivative 11 remained inactive against the parasite kinase. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 1692-25-7