Fricke, Patrick J.; Dolewski, Ryan D.; McNally, Andrew published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Four-Selective Pyridine Alkylation via Wittig Olefination of Dearomatized Pyridylphosphonium Ylides》.Recommanded Product: 1692-25-7 The article contains the following contents:
Methods to synthesize alkylated pyridines are valuable because these structures are prevalent in pharmaceuticals and agrochems. A distinct approach to construct 4-alkylpyridines using dearomatized pyridylphosphonium ylide intermediates in a Wittig olefination-rearomatization sequence is reported. Pyridine N-activation is key to this strategy, and N-triazinylpyridinium salts enable coupling between a wide variety of substituted pyridines and aldehydes. The alkylation protocol is viable for late-stage functionalization, including methylation of pyridine-containing drugs. This approach represents an alternative to metal-catalyzed sp2-sp3 cross-coupling reactions and Minisci-type processes. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 1692-25-7