Zhong, Rui; Wei, Zeyuan; Zhang, Wei; Liu, Shun; Liu, Qiang published the artcile< A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is cobalt complex catalyst preparation; secondary alc primary preparation diastereoselective; ketone hydrogenation cobalt catalyst; aldehyde hydrogenation cobalt catalyst.
Herein, a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2 and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610) to afford alcs. was reported. This was the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Addnl., a bis(NHCs)-Co complex was successfully isolated and fully characterized and it exhibited excellent catalytic activity that equals that of the in-situ-formed catalytic system.
Chem published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.