Zhang, Lin; Zhang, Ling; Chen, Qian; Li, Linlin; Jiang, Jian; Sun, Hao; Zhao, Chong; Yang, Yuanyong; Li, Chun published the artcile< Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones>, Application of C7H7NO, the main research area is cinchona alkaloid based NNP ligand catalyst preparation DFT; chiral secondary alc enantioselective preparation; ketone hydrogenation iridium cinchona alkaloid based NNP ligand.
Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC6H4, etc.; R1 = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified.
Organic Letters published new progress about Cinchona alkaloids Role: CAT (Catalyst Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application of C7H7NO.