Barone, Antonella; Cristiano, Maria Chiara; Cilurzo, Felisa; Locatelli, Marcello; Iannotta, Dalila; Di Marzio, Luisa; Celia, Christian; Paolino, Donatella published the artcile< Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is ammonium glycyrrhizate skin drug delivery antiinflammatory activity; Ammonium glycyrrhizate; Anti-inflammatory activity; Colloidal nanocarriers; Topical administration; Ultradeformable liposomes.
Although several nanoformulations, such as ethosomes, are designed to provide a systemic effect through a topical application, there are different limitations to the distribution inside the blood stream. For this reason, ultradeformable liposomes, or transfersomes, are selected to improve the topical delivery of drugs and allow the distribution of payloads in the blood stream because they pass intact through the stratum corneum epidermis barrier, due to the presence of sodium cholate, aqueous cutaneous gradient, and the rapid penetration of transfersomes by cutaneous tight junctions, thus allowing the systemic delivery of different therapeutic cargo in non-occlusive conditions. The aim of this work was the synthesis and physicochem. characterization of the ammonium glycyrrhizinate-loaded ultradeformable liposomes, the evaluation of drug release and permeation through stratum corneum and epidermis barrier. The in vivo anti-inflammatory effect of ammonium glycyrrhizinate-loaded ultradeformable liposomes was tested on human healthy volunteers. The results demonstrated that the ammonium glycyrrhizinate-loaded ultradeformable liposomes decreased the skin inflammation on the human volunteers and the resulting nanoformulations can be used as a potential topical drug delivery system for anti-inflammatory therapy.Parts of these results were presented as a poster communication at the Recent Developments in Pharmaceutical Anal. 2019 (RDPA 2019), Chieti, Italy.
Colloids and Surfaces, B: Biointerfaces published new progress about Anti-inflammatory agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.