A new synthetic route of 5-Bromo-2-chloropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53939-30-3, 5-Bromo-2-chloropyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53939-30-3, name is 5-Bromo-2-chloropyridine, molecular formula is C5H3BrClN, molecular weight is 192.44, as common compound, the synthetic route is as follows.HPLC of Formula: C5H3BrClN

EXAMPLE 13-(2-Methoxyphenyl)-6-(4-methoxyphenyl)-[l,2,4]triazolo[4,3-a]pyridine a) 5-Bromo-2-hydrazinylpyridine. A mixture of 5-bromo-2-chloropyridine (11.5 g, 60 mmol) and hydrazine hydrate (100 mL) was refluxed under Argon for 2 h. The mixture was cooled to room temperature, filtered and the solids were washed with water (50 mL x 3), dried to give the title compound (8.30 g, 74.4% yield) as yellow solids. MS: m/z 188.0 [M+H+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53939-30-3, 5-Bromo-2-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; IMPACT THERAPEUTICS, INC.; DONG, Haijun; CAI, Suixiong; TIAN, Ye Edward; CHEN, Lei; YU, Zenghui; YIN, Feng; BI, Sheng; LIU, Lijun; WU, Lizhen; WO2012/65297; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem