Sun, Manman; Wu, Haijian; Xia, Xiangyu; Chen, Weida; Wang, Zhiming; Yang, Jianguo published the artcile< Asymmetric Palladium-Catalyzed C-H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones>, Formula: C13H15F3N2O, the main research area is sulfonylbenzamide diene palladium bond activation enantioselective allylation cascade green; dihydroisoquinolone stereoselective preparation.
A palladium-catalyzed C-H functionalization/intramol. asym. allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine-oxazoline ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones, e.g., I, in yields of up to 83% with enantioselectivities of up to 96%, using environmentally friendly air as the terminal oxidant.
Journal of Organic Chemistry published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.