Estabrook, Daniel A.; Day, Rachael A.; Sletten, Ellen M. published the artcile< Redox-Responsive Gene Delivery from Perfluorocarbon Nanoemulsions through Cleavable Poly(2-oxazoline) Surfactants>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is polyoxazoline surfactant perfluorocarbon nanoemulsion redox responsive gene delivery; emulsions; gene delivery; interfacial chemistry; poly(2-oxazoline); stimuli-responsive carriers.
The clin. utility of emulsions as delivery vehicles is hindered by a dependence on passive release. Stimuli-responsive emulsions overcome this limitation but rely on external triggers or are composed of nanoparticle-stabilized droplets that preclude sizes necessary for biomedical applications. Here, we employ cleavable poly(2-oxazoline) diblock copolymer surfactants to form perfluorocarbon (PFC) nanoemulsions that release cargo upon exposure to glutathione. These surfactants allow for the first example of redox-responsive nanoemulsions in cellulo. A noncovalent fluorous tagging strategy is leveraged to solubilize a GFP plasmid inside the PFC nanoemulsions, whereupon protein expression is achieved selectively when employing a stimuli-responsive surfactant. This work contributes a methodol. for non-viral gene delivery and represents a general approach to nanoemulsions that respond to endogenous stimuli.
Angewandte Chemie, International Edition published new progress about Drug delivery systems. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.