Kassem, Salma; Lee, Alan T. L.; Leigh, David A.; Markevicius, Augustinas; Tetlow, Daniel J.; Toriumi, Naoyuki published the artcile< Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm>, Application of C10H8N2S2, the main research area is small mol robotic arm peptide transport.
Peptides attached to a cysteine hydrazide ‘transporter module’ are transported selectively in either direction between two chem. similar sites on a mol. platform, enabled by the discovery of new operating methods for a mol. transporter that functions through ratcheting. Substrate repositioning is achieved using a small-mol. robotic arm controlled by a protonation-mediated rotary switch and attachment/release dynamic covalent chem. A polar solvent mixtures were found to favor Z to E isomerization of the doubly-protonated switch, transporting cargo in one direction (arbitrarily defined as ‘forward’) in up to 85% yield, while polar solvent mixtures were unexpectedly found to favor E to Z isomerization enabling transport in the reverse (‘backward’) direction in >98% yield. Transport of the substrates proceeded in a matter of hours (compared to 6 days even for simple cargoes with the original system) without the peptides at any time dissociating from the machine nor exchanging with others in the bulk. Under the new operating conditions, key intermediates of the switch are sufficiently stabilized within the macrocycle formed between switch, arm, substrate and platform that they can be identified and structurally characterized by 1H NMR. The size of the peptide cargo has no significant effect on the rate or efficiency of transport in either direction. The new operating conditions allow detailed phys. organic chem. of the ratcheted transport mechanism to be uncovered, improve efficiency, and enable the transport of more complex cargoes than was previously possible.
Chemical Science published new progress about Peptides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.