Schirrmacher, Ralf; Wangler, Bjorn; Schirrmacher, Esther; August, Thorsten; Rosch, Frank published the artcile< Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is dimethylpyridinylamine catalyzed alcoholysis nucleophilicity aminotrimethylpurinylammonium chloride; guanine alc derivative preparation.
Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.
Synthesis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.