Eremina, Julia A.; Lider, Elizaveta V.; Samsonenko, Denis G.; Sheludyakova, Liliya A.; Berezin, Alexey S.; Klyushova, Lyubov S.; Ostrovskii, Vladimir A.; Trifonov, Rostislav E. published the artcile< Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2'-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity>, Category: pyridine-derivatives, the main research area is crystal structure copper phenanthroline bipyridine tetrazole; copper phenanthroline bipyridine phenyltetrazole tetrazole preparation cytotoxicity human.
The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, were synthesized. All complexes were characterized by elemental anal., IR, EPR spectroscopy and x-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, and 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of the compounds on viability of the MCF-7 and Hep-2 cell lines was studied in vitro. Tetrazole ligands HL1 and HL2 are nontoxic at tested concentrations (1-50 μM), while 1,10-phen and 2,2′-bipy possess cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) also were obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.
Inorganica Chimica Acta published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.