He, Yu-Ping; Cao, Jian; Wu, Hua; Wang, Qian; Zhu, Jieping published the artcile< Catalytic Enantioselective Aminopalladation-Heck Cascade>, Application In Synthesis of 1416819-91-4, the main research area is alkynylaniline cyclopentene diastereoselective enantioselective palladium pyrox aminopalladation Heck cascade; indole cyclopentene stereoselective preparation; asymmetric synthesis; domino reactions; homogeneous catalysis; nucleopalladation; oxidative Heck reactions.
Domino processes initiated by intramol. nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains scarce. We report herein that reaction of 2-alkynylanilines with prochiral cyclopentenes in the presence of a catalytic amount of Pd(OAc)2, a chiral bidentate pyrox ligand and O2 as terminal oxidant affords the structurally diverse indole-cyclopentene conjugates, e.g., I, bearing two stereocenters in a highly diastereo- and enantio-selective manner. One of the products is converted to a heavily functionalized tetracyclic indolinone derivative
Angewandte Chemie, International Edition published new progress about Addition reaction, aminopalladation. 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application In Synthesis of 1416819-91-4.