Andaloussi, Mounir; Moreau, Emmanuel; Masurier, Nicolas; Lacroix, Jacques; Gaudreault, Rene C.; Chezal, Jean-Michel; El Laghdach, Anas; Canitrot, Damien; Debiton, Eric; Teulade, Jean-Claude; Chavignon, Olivier published the artcile< Novel imidazo[1,2-a]naphthyridinic systems (Part 1): Synthesis, antiproliferative and DNA-intercalating activities>, Safety of 6-Amino-3-nitro-2-picoline, the main research area is imidazonaphthonaphthyridine preparation antiproliferative DNA intercalation.
Novel imidazo[1,2-a]naphthyridine systems were obtained from Friedlaender’s reaction in imidazo[1,2-a]pyridine series. The compounds were evaluated for their antitumor activity in the NCIs in vitro human tumor cell line screening panel. Among them, 7,8-dihydroimidazo[1,2-a]naphtho[2,1-g][1,5]naphthyridine and 8,9-dihydroimidazo[1,2-h]naphtho[1,2-b][1,7]naphthyridine exhibited in vitro activity comparable to anticancer agent such as amsacrine. Their mechanism of cytotoxic action was unrelated to poisoning or inhibiting abilities against topo1. On the contrary, a direct intercalation of the drugs into DNA was observed by electrophoresis on agarose gel.
European Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 6-Amino-3-nitro-2-picoline.