Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou published the artcile< Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst>, Application of C6H8N2, the main research area is aerobic activation amine nanorod manganese oxide catalyst; amide preparation green chem.
The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.
ChemCatChem published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.