Synthetic Route of C7H6BrNO2In 2014 ,《Synthesis and Late-Stage Functionalization of Complex Molecules through C-H Fluorination and Nucleophilic Aromatic Substitution》 appeared in Journal of the American Chemical Society. The author of the article were Fier, Patrick S.; Hartwig, John F.. The article conveys some information:
The authors report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are installed. This functionalization is accomplished by a combination of fluorination and nucleophilic aromatic substitution of the installed fluoride. A diverse array of functionalities can be installed because of the mild reaction conditions revealed for nucleophilic aromatic substitutions (SNAr) of the 2-fluoroheteroarenes. An evaluation of the rates for substitution vs. the rates for competitive processes provides a framework for planning this functionalization sequence. This process is illustrated by the modification of medicinally important compounds, as well as the increase in efficiency of synthesis of several existing pharmaceuticals. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Synthetic Route of C7H6BrNO2)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Synthetic Route of C7H6BrNO2